Every moment is a revelation of the Four Noble Truths. What kind of suffering do we have influence over? Once we deeply understand the nature of impermanence, freedom from suffering is close at hand.
Every thing changes...the only thing that we can know for sure... the only thing that we can 'hold on to' is the truth. Direct experience of impermanence is the gateway to liberation.
It's very helpful to reflect on the way we experience change in the course of our human life, including our own aging and death. But even more freeing is discovering the direct insight into the momentary arising and passing of all phenomena through our practice of mindful observation.
Although humans have a bias toward falsely seeing permanence, we can develop the insight into the truth of impermanence. In the depths of meditation, we are able to discern the moment to moment dissolution of our experience at the six sense doors.